Avana 200 is a modern drug for the treatment of erectile dysfunction with the active substance avanafil. The advantage of avanafil is that it has a very fast onset of action compared to other PDE5 inhibitors. It is rapidly absorbed and reaches maximum serum concentration in about thirty to forty-five minutes.
Avana 200 mg contains avanafil – a phosphodiesterase type 5 inhibitor used to treat erectile dysfunction (sexual impotence) in men. In combination with sexual stimulation, avanafil works by increasing blood flow to the penis to help a man get and keep an erection. Manufactured by Sunrise Remedies Pvt. Ltd. in clinical conditions, Avana 200 is produced to a high-quality standard to ensure its safety and effectiveness.
Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5. When sexual stimulation causes the local release of nitric oxide, the inhibition of PDE5 by avanafil produces increased cGMP levels in the corpus cavernosum of the penis. This action results in smooth muscle relaxation and the inflow of blood into the penile tissues (a widening of blood vessels), thereby producing an erection. This allows men to keep an erection hard enough for sex.
To learn more about the medicine's inner workings, read the contents of the How it works tab.
Avana 200 was assessed for its effect on men's ability with erectile dysfunction (ED) to achieve and maintain an erection sufficient for satisfactory sexual activity. The drug produced erections considered adequate for penetration in some men as early as 15 minutes after dosing.
Among the benefits of Avana 200 are:
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Along with its needed effects, erectile dysfunction pills containing avanafil may cause some unwanted effects. Although not all of these side effects may occur, they may need medical attention if that happens.
Commonly reported side effects of Avana 200 are:
Avana 200 does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity.
For a comprehensive list of adverse effects, check the content of the Side Effects tab.
To get the best from your treatment, please read the following carefully:
Avoid grapefruit or grapefruit products close to the time when you intend to take medication. Do not take this medication with any other product that contains avanafil or other similar drugs used to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil or vardenafil). Do not take Avana 200 mg if you are also taking the drug Riociguat. More details are available under the Administration and Contraindications tab.
To get the most of the medicine, be sure to check out the contents of Tips and Warning tabs as well.
To get the best from your Avana 200 mg treatment, please read the following carefully:
Take this medication by mouth with or without food as directed by your doctor, usually as needed. If Avana 200 mg is taken with food, the onset of activity may be delayed compared to the fasted state.
This medication is available in different doses. The recommended dose is 100 mg taken as needed approximately 15 to 30 minutes before sexual activity. Based on individual efficacy and tolerability, the dose may be increased to a maximum dose of 100 mg or decreased to 50 mg. The maximum recommended dosing frequency is once per day. Sexual stimulation is required for a response to treatment. Follow your doctor's instructions carefully on how many minutes before sexual activity you should take this medication.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Along with its needed effects, Avana 200 mg may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Sexual activity may put extra strain on your heart, especially if you have heart problems. If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away:
Rarely, sudden decreased vision, including permanent blindness, in one or both eyes (NAION) may occur. If this serious problem occurs, stop taking Avana 200 mg and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.
Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Stop taking Avana 200 mg and get medical help right away if these effects occur.
In the rare event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and get medical help right away, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
Avana 200 mg has minor influence on the ability to drive and use machines. As dizziness and altered vision were reported in clinical trials with avanafil, patients should be aware of how they react to Avana 200 mg before driving or using machines.
Before taking Avana 200 mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Patients who experience erections lasting 4 hours or more (priapism) should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Avanafil should be used with caution in patients with anatomical deformation of the penis, or in patients who have conditions which may predispose them to priapism (such as sickle cell anaemia, multiple myeloma or leukaemia).
The concomitant use of alpha-blockers and avanafil may lead to symptomatic hypotension in some patients due to additive vasodilatory effects.
This drug may make you dizzy or cause vision changes. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension. Talk to your doctor if you are using marijuana or alcohol.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call doctor or emergency immediately.
Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
A product that may interact with this drug is: Riociguat.
Avana 200 mg can cause a serious drop in your blood pressure when used with nitrates, which can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use Avana 200 mg with any of the following:
If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of avanafil to minimize your risk of low blood pressure.
Patients with left ventricular outflow obstruction (e.g. aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure can be particularly sensitive to the actions of vasodilators including avanafil.
Other medications can affect the removal of avanafil from your body, which may affect how Avana 200 mg works. Examples include:
Although specific interactions have not been studied, other inhibitors, including grapefruit juice would likely increase avanafil exposure. Patients should be advised to avoid grapefruit juice within 24 hours prior to taking avanafil.
Do not take this medication with any other product that contains avanafil or other similar medications used to treat erectile dysfunction-ED or pulmonary hypertension (such as Sildenafil, Tadalafil, Vardenafil).
Avanafil was assessed for its effect on the ability of men with erectile dysfunction (ED) to achieve and maintain an erection sufficient for satisfactory sexual activity. Avana 200 mg produced erections considered sufficient for penetration in some men as early as 20 minutes after dosing and overall response of these subjects to avanafil was statistically significant, compared to placebo. Avanafil is rapidly absorbed after oral administration, within 30 to 45 minutes.
Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5. When sexual stimulation causes the local elease of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. This results in smooth muscle relaxation and inflow of blood into the penile tissues (a widening of blood vessels), thereby producing an erection. Avanafil has no effect in the absence of sexual stimulation. High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of blood vessels and muscles.
Avanafil belongs to the class of medicines known as PDE-5 inhibitors. It increases blood flow to the penis following sexual stimulation. It does this by blocking the enzyme responsible for the breakdown of cGMP. This allows men to keep an erection hard enough for sex. Avana 200 mg may affect the way other medicines work, and other medicines may affect the way Avana 200 mg works, causing side effects.
Avana 200 mg does not protect you or your partner from getting sexually transmitted diseases, including HIV – the virus that causes AIDS.
Do not take more than one dose of Avana 200 mg per day.
Do not consume grapefruit or grapefruit products while taking Avana 200 mg.
Always talk to your doctor before taking ANY medication for erectile dysfunction. Some erectile dysfunction medications are not suitable for men with certain medical conditions, and your doctor can advise you on an alternative.
Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, tingling in your chest, arms, neck, or jaw.
Do not take Avana 200 mg if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems. Do not take Avana 200 mg with recreational drugs such as "poppers". Taking these substances together can cause a sudden and dangerous drop in blood pressure.
Always buy your medications from a reputable supplier as there are a lot of counterfeit products on the market.
Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can impact on erectile dysfunction. Eliminating these may also help improve the erection. For example:
Never take other erectile dysfunction medications at the same time as taking Avana 200 mg.
Seek urgent medical advice if an allergic reaction, sudden vision loss or painful erections lasting more than four hours occur.
Drinking alcohol after taking Avana 200 mg may lower blood pressure and decrease sexual performance.
